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beplay网页版登录:What is Alternative Splicing?

In human DNA, approximately 20,000 genes code for hundreds of thousands of distinct proteins required for normal tissue development and function. This is possible because a single gene can translate into multiple protein variants, with distinct and sometimes opposing function, through a dynamic and heavily regulated mechanism known as alternative pre-mRNA splicing, commonly known as alternative splicing.

beplay网页版登录:Alternative pre-mRNA Splicing and Disease

Alternative splicing regulates genome potential by differentially joining or skipping gene segments at alternative splice sites. The resulting proteome diversification is a fundamental physiological aspect of tissue fate and function. Conversely, dysregulated alternative splicing can be a root cause of developmental disorders, tissue degeneration and cancer.

beplay网页版登录:What We Do

Biosplice Therapeutics has produced fresh biological insights and unique chemical equity that delivers therapeutic modulation of alternative splicing by targeting the CLK/DYRK family kinases. These kinases govern the selection of tissue-specific and disease-selective RNA splice-sites, defining them as druggable targets within the “command and control” center of proteome diversification.

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